Coexisting vertical and horizontal one and a half syndromes.

Supranuclear ocular movements comprise chiefly vertical and horizontal movements; horizontal movements are controlled by the subcortical centres located mainly at the pontine level and vertical movements at the level of the rostral midbrain. 2 The classic one and a half syndrome is produced by a unilateral pontine tegmental lesion that includes the paramedian pontine reticular formation and medial longitudinal fasciculus on the same side, and has been considered an important ocular sign in neurological diagnosis. 3 4 Vertical, as distinct from horizontal, one and a half syndrome, has also been documented recently. 2 5 6 We report on a patient with concurrent vertical and horizontal one and a half syndromes. A 57 year old man was admitted to hospital with a sudden onset of dysarthria and loss of consciousness while playing golf. He had a history of aortic regurgitation and heart failure 8 years previously, and underwent aortic valve replacement 5 years previously, when he started to take oral antiplatelet and anticoagulant drugs. On admission, he was comatose, and his blood pressure was 140/76 mm Hg. He also had atrial fibrillation, Cheyne-Stokes respiration, bilateral miosis, and a positive Babinski’s sign. Brain CT showed lesions suspected of being infarcts in the right medial thalamus and the left upper cerebellum. According to neurological findings on day 4 after onset of disease, he was in a state of hypersomnia. While awake, his head tilted slightly to the left, the right eye was slightly deviated upward, the left eye slightly downward, and there was bilateral miosis. For horizontal ocular movements, only the right eye could abduct with monocular horizontal nystagmus. Also, there was bilateral conjugated leftward palsy, indicating horizontal left one and a half syndrome. On the other hand, for vertical ocular movement, only the left eye could gaze downward. Also, diYculty in downward gaze of the right eye and bilateral conjugated upward palsy, indicating vertical one and a half syndrome, were noted (figure A). Doll’s eye test (oculocephalic reflex) was weak but positive, and the eyes were unable to converge. There was also ataxic dysarthria, cerebellar ataxia of the left limbs and trunk, right sided hemisensory disturbance, and bilaterally positive Babinski’s sign. Brain MRI showed infarcts in the right medial thalamus, left dorsal portion of the upper midbrain, and left upper cerebellum (figure B). On magnetic resonance angiography performed at the same time, partial obstruction of the left posterior cerebral artery was noted at its origin. Cardiogenic cerebral embolism was suspected in the pathogenesis of the serial episode in this patient. At 7 days the patient still tended to become unconscious, accompanied by CheyneStokes respiration, when talking to a familiar person. About 1 month later he talked about occurrences at the onset and began to show an interest in his surroundings. At 2 months, adduction of the left eye, bilateral leftward gaze, downward gaze of the right eye, and bilateral upward gaze showed moderate improvement. The gait disturbance persisted and he is still in a wheelchair. Classic horizontal one and a half syndrome is commonly caused by a vascular accident